Synthesis and <i>In Vitro</i> Anti-Helicobacter and Anti-Staphylococcal Activities of Novel Diaryldisulfides and Diarylthiosulfonates

Arylthiols were reacted with acrylonitrile under basic conditions to form the corresponding aryl sulfides which oxidised sodium metaperiodate in aqueous methanol yield 3-arylsulphinylpropanenitriles that upon thermolysis refluxing toluene produced a mixture of diarylthiosulfonates and diaryldisulfides. The two products was easily separated by flash chromatography characterized spectroscopically. diaryldisulfides, garlic-like organosulfur compounds, tested for their antimicrobial properties against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus Helicobacter pylori had been found have good activity S. aureas H. no other organisms.